Effects of the piezoelectricity of polyvinylidene fluoride (PVDF) on sliding friction against itself are investigated in this research. The piezoelectricity is the response of a piezoelectric material, such as PVDF, to an applied electrical voltage in terms of stress or physical dimension. Such a response is found to influence the sliding-frictional behavior. This research is beneficial in terms of understanding fundamental friction. The applications of this research are in wide areas, such as the design of a microgripper used for surgeries, microassembly, and micromanipulation.