Reducing the frictional loss in internal combustion engines (ICE) represents a challenge, in which all car manufacturers are involved. This concern has two origins. The first one is the fuel cost, which increases over the years. The second is strongly linked to ecology: people feel more and more concerned by the greenhouse effect, partly resulting from fuel consumption. Many projects involving several laboratories and lead by car manufacturers have this particular point as main subject, with the goal to reduce the ICE fuel consumption by decreasing the friction power loss. This aim can be partly achieved with a better knowledge of the connecting rod big-end bearing functioning. A lot of theoretical and experimental studies have been carried out, resulting in efficient models for numerical simulations, but at the time, no known ambitious parametric study has been planned, to determine the most influent parameters and to quantify their effects on power loss. The present work is a first step to bridge the gap between the potential of recent numerical simulations and the need for a better understanding of the connecting rod big-end bearing functioning. To plan the numerical simulations, it will be taken advantage of design of experiment techniques, which provide an efficient way of preparing the series of experiments with a minimum of runs. Thus, these techniques are illustrated through the variable combination run, test results generated, and interpretations made to identify the dominate factors impacting the responses of interest.