In this paper, the analyses of elastohydrodynamic lubrication (EHL) of crankshaft bearings considering the deformation of the whole cylinder block and crankshaft under load were carried out for the crankshaft bearing system of a four-stroke four-cylinder internal combustion engine. The lubrication of crankshaft bearing was analyzed by dynamic method. The deformation of bearing surface under pressure of oil film was calculated by compliance matrix method. The results show that when the crankshaft deformation under load is considered, compared with the results of not considering the deformation of cylinder block, the maximum film pressure decreases, the minimum film thickness increases, and the end leakage flow-rate and frictional coefficient of journal surface change little in an engine working cycle when considering the deformation of cylinder block. The models of the whole cylinder block and the single main bearing housing were used, respectively, to calculate the deformation of main bearing surface in the analyses. The results show that the calculation accuracy of the elastohydrodynamic lubrication analyses of crankshaft main bearings can be met basically by applying the simple model based on the single main bearing housing to calculate the elastic deformation of main bearing surface.